Healthcare Professionals
Information for doctors – General
For GPs and consultants (e.g. gynaecologists, urologists, andrologists, oncologists)
Bourn Hall Clinic is keen to co-operate with you and the patients you refer. We provide specialised services to individuals and couples who need help with the investigation and management of their infertility. We can also offer gamete or embryo cryopreservation to patients before surgery, radiotherapy or chemotherapy and sperm freezing pre-vasectomy procedures.
To refer a self-funding patient, please write to our Medical Director – Dr Thomas Mathews – with a summary of the patient’s history, investigations and/or treatments to date. For East of England NHS referrals, please see the East of England Specialist Commissioning Group website.
To discuss the possibility of Bourn Hall Clinic managing the infertility of one of your patients, please email thomas.mathews@bourn-hall.com to suggest a convenient time for him to call you.
If you’d like to visit and see our Clinic’s facilities, or just ask Dr Mathews a question, simply email thomas.mathews@bourn-hall.com and he will get back to you.
We have published a leaflet with advice for patients and to help them through the referral process entitled Fertility: what you need to know. If you would like a supply of leaflets for your practice or clinic just give us a call or email at your convenience.
Information for doctors – Publications
We have a wealth of knowledge and unrivalled experience. We carry out around over 2,000 treatment cycles per year and continue to improve our success rates and range of treatments through our research.
Books
| Date | |||
| 2013 | Variable imprinting of the MEST gene in human preimplantation embryos | Huntriss JD, Hemmings KE, Hinkins M, Rutherford AJ, Sturmey RG, Elder K, Picton HM | Eur J Hum Genet. 2013 Jan:21 (1):40-7 |
| 2012 | |||
| 2012 | Embryo Co-culture. In “Embryo Culture: Advances, Controversies and Future Considerations” Eds Smith, Paul & Swain | Ménézo YJR, Servy E, Veiga A, Hazout A, Elder K | Humana Press (in press) |
| 2011 | In-Vitro Fertilisation (3rd Edition) | Elder K, Dale B | Cambridge University Press |
| 2010 | In-Vitro Fertilisation, Chapter 9, pg 135-148 In “Oocyte Maturation and Fertilization: A Long History for a Short Event”, 2010, Eds E. Tosti & R.Boni | Elder K | Bentham Science Publishers Ltd, ISBN 978-1-60805-182-3 |
| 2009 | Preimplantation Embryo Development. In: Preimplantation Genetic Diagnosis | Elder K | Ed Harper, CUP 2009 |
| 2007 | Human Preimplantation Embryo Evaluation and Selection | Elder KT & Cohen JC | Taylor-Francis, London |
| 2005 | A Textbook of In Vitro Fertilization and Assisted Reproduction (3rd Edition), ed. Brinsden, Taylor Francis | Taylor-Francis. London | |
| 2004 | Infections, infertility and assisted reproduction. | Elder, K.T., Baker, D.J. and Ribes, J.A | Cambridge University Press |
| 2001 | In Vitro Fertilization (2nd Edition) | Elder KT & Dale B | Cambridge University Press |
| 2000 | A Textbook of In Vitro Fertilization and Assisted Reproduction (2nd Edition) | Brinsden PR | Parthenon Press, London |
| 2000 | Legislation and regulation in assisted reproduction practice. | Elder, K. T., Pacey, A., & Elliott, T. | Worldwide Conferences in Reproductive Biology, Ladybrook Publishing, Australia |
| 2000 | Micromanipulation in Assisted Reproductive Biology. | Elder, K.T.,Glew, A & Elliott, T | Worldwide Conferences in Reproductive Biology, Ladybrook Publishing, Australia |
| 1999 | Problem solving and trouble shooting in IVF | Elder, K.T., & Elliott, T | Worldwide Conferences in Reproductive Biology, Ladybrook Publishing, Australia |
| 1999 | Blastocyst Update | Elder, K.T., & Elliott, T | Worldwide Conferences in Reproductive Biology, Ladybrook Publishing, Australia |
| 1998 | The use of testicular and epididymal sperm in IVF. | Elder, K.T., & Elliott, T | Worldwide Conferences in Reproductive Biology, Ladybrook Publishing, Australia |
| 1997 | Blastocyst culture, transfer, and freezing | Elder, K.T., & Elliott, T | Worldwide Conferences in Reproductive Biology, Ladybrook Publishing, Australia |
| 1997 | In Vitro Fertilization (1st Edition) | Elder KT & Dale B | Cambridge University Press |
| 1992 | A Textbook of In Vitro Fertilization and Assisted Reproduction (1st Edition) | Brinsden PR & Rainsbury PA (Eds) | arthenon Press, London |
| 1984 | Edwards, R.G., Purdy J.M. & Steptoe PC | Implantation of the Human Embryo | Academic Press, London New York |
| 1982 | Edwards, R.G. & Purdy J.M | Human Conception In Vitro | Academic Press, London New York |
Journal Publications
| Date | |||
| 2012 | Human hypoblast formation is not dependent on FGF signalling | Roode M, Blair K, Snell P, Elder K, Marchant S, SMith A, Nichols J | Dev Biol. 2012 Jan 15; 361 (2): 358-63. |
| 2012 | Culture Systems: embryo co-culture | Menezo YJ, Servy E, Veiga A, Hazout A, Elder K | Methods Mol Biol. 2012;912:231-47 |
| 2012 | Embryos under surveillance! | Kay Elder | RBM Online Vol 25 Issue 4 Pages 337-338 |
| 2011 | Global DNA Methylation Profiling of Single Human Blastocysts on CpG Island Arrays – Awarded Best Overall Scientific Presentation at the British Fertility Society Annual Meeting, Dublin, January 2011 | Huntriss, J., Elder, K., Hemmings, K., Miller, D., H.M (2011) | In press |
| 2010 | Egg sharing for assisted conception: a window on oocyte quality | Dr Malcolm Faddy, Dr Kay Elder | RBM Online (2011) 22,88-93 |
| 2010 | Quantitative Methylation Analysis of Multiple Imprinted Gene Differentially Methylated Regions in Single Human Blastocysts by Pyrosequencing | Huntriss, J. 1*; Woodfine, K. 2; Huddlestone, J. 2; Murrell A. 2; Rutherford, A. 3; Elder, K. 4; Hemmings, K1.; Picton, H.M.1 | In press |
| 2009 | Length of androgen receptor-CAG repeats in fertile and infertile Egyptian men. | Badran WA, Fahmy I, Abdel-Megid WM, Elder K, Mansour R, Kent-First M. | J Androl. 2009 Jul-Aug;30(4):416-25. Epub 2009 Jan 22. |
| 2008 | The rates of de novo meiotic deletions and duplications causing several genomic disorders in the male germline. | Turner DJ, Miretti M, Rajan D, Fiegler H, Carter NP, Blayney ML, Beck S. Hurles ME. | Nature Genetics, 2008 Jan 40 (1):90-5 |
| 2008 | Impact of gonadotrophin stimulation for assisted reproductive technology on ovarian ageing and menopause | K Elder, T Mathews, E Kutner, E Kim, D Espenberg, M Faddy, R Gosden | RBMonline 2008 16 (5):611/616 |
| 2008 | Responsibility and accountability of authors and co-authors. | T Tulandi, K Elder, J Cohen | RBMonline 2008 16 (6):763/764 |
| 2008 | Optimal follicle and oocyte numbers for cryopreservation of all embryos in IVF cycles at risk of OHSS | GR Verwoerd, T Mathews, P Brinsden | RBMonline 2008 17 (3):312/317 |
| 2006 | Explaining success rates in IVF | Elder, KT (2006) | Capital Doctor 50:17-18, Jan 2006 |
| 2006 | Infection control in the IVF laboratory. | Elder, KT (2006) | Embryo Talk 1,1:36-42 |
| 2006 | Treatment strategies in assisted reproduction for women of advanced maternal age | Colin M Howles, Chung-Hoon Kim and Kay Elder (2006) | Int Surg 91:S37-S54 |
| 2006 | Soluble HLA-G release by the human embryo: An interesting artefact ? | Yves Ménézo, Kay Elder and Stephane Viville | RBMonline 13 (6), October 2006 :763-764 |
| 2006 | Case report: Unusual presentation of a woman with polycystic ovaries and complex endometrial pathology. | K Marikinti | Reproductive Biomed Online Volume 12, No 1 January 2006 |
| 2005 | ‘The presence of blood in the transfer catheter negatively influences outcome at embryo transfer’. | Marikinti K, Brinsden PR. | Hum Reprod. 2005 Jul; 20(7): 2029-30. |
| 2005 | Implantation failures: success with quarter laser zona thinning assisted hatching | Petersen CG, Mauri AL, Baruffi RL, Oliveira JBA, Massaro FC, Elder K and Franco Jr JG (2005). | RBMonline, 10(2):224-229 |
| 2004 | Cytoplasmic transfer in oocytes: biochemical aspects | Levy, R., Elder, K., & Menezo, Y. (2004 | Human Reproduction Update 10:1-10 |
| 2004 | Oocyte number per live birth in IVF: were Steptoe and Edwards less wasteful? | Inge, G., Brinsden, PR, Elder, KT (20040) | Human Reproduction, 20(3): 588-59 |
| 2004 | IVF laboratory cleaning protocols. | Elder, KT and Elliott, T (2004) | JARG 21:63-64 |
| 2003 | Spindle position in ICSI | Avery, S., Blayney, M. L. | Human Fertility. 6 19-22. |
| 2003 | Choosing the right embryo: towards single embryo transfer | Elder, KT (2003) | Journal of the Federation of Latin American Fertility Societies (FLASEF), (translated into Spanish) |
| 2003 | Quality control in ART | Elder, KT & Kastrop, P (2003) | Journal of the Federation of Latin American Fertility Societies (FLASEF), in(translated into Spanish) |
| 2002 | Livebirth resulting from emergency TESE, after unexpected three consecutive total necrozoospermic samples on day of oocyte recovery: a case report. | Marcus, S. F., Blayney, M. L., Louis, E., Burnley, A. Brinsden, P. | Middle East Fertility Society Journal. 7(2) 2002;145-148. |
| 2001 | A physiological replacement for polyvinylpyrrolidone (PVP) in assisted reproductive technology | Barak, Y., Menezo, Y., Veiga, A., and Elder, K., (2001) | Human Fertility (2001) 4 99-103 |
| 2000 | Treatment by in vitro fertilisation with surrogacy: experience of one British centre | Brinsden, P. R., Appleton, T. C., Murray, E., Hussein, M., Akagbosu, F., a, S. F., (2000) | BMJ Volume 320 1 April 2000 Eduction and Debate |
| 2000 | Has clinical practice been changed by the Human Fertilisation and Embryology Act 1990? | Brinsden, P. R., (2000) | Human Fertility (2000) 3, 116-12 |
| 2000 | The case for routine HIV screening before IVF treatment: A survey of UK IVF centre policies | Marcus S F, Avery S M, Abusheikha n, Marchus n K, and Brinsden P, (2000) | Human Reproduction vol 15 no 8 pp 1657-1661 2000 |
| 1999 | Regulation of assisted reproductive technology The UK Experience | Brinsden, P (1999) | In Vitro Fertilization and Assisted Reproduction pp 415 – 446 |
| 1999 | How useful is cervical dilation in patients with cervical stenosis who are participating in an in vitro fertilization-embryo transfer program? The Bourn Hall experience | Abusheikha N., Lass A., Akagbosu, F., & Brinsden, P., (1999) | Fertility and Sterility Vol 72 No 4 October 1999 |
| 1999 | Letters to the Editor The effect of a difficult embryo transfer on the outcome of IVF | Lass, L., (1999) | Human Reproduction vol 14 no 9 pp 2417-2420 1999 |
| 1999 | The effect of a difficult embryo transfer on the outcome of IVF | Lass, A., Abusheikha, N., & Brinsden, P (1999) | Human Reproduction Update 1999 Vol 5 no 3 pp 256-266 |
| 1999 | Cancer Patients should be offered semen cryopreservation | Lass, A., (1999) | BMJ Vol 318 5 June 1999 |
| 1999 | The role of ovarian volume in reproductive medicine | Lass, A.and Brinsden, P (1999) | Human Reproduction Update 1999 Vol 5 no 3 pp 256-266 |
| 1998 | A programme of semen cryopreservation for patients with malignant disease in a tertiary infertility centre: lessons from 8 years’ experience | Lass, A., Akagbosu, F., Blayney, M., Avery, S., Brinsden, P., et al (1998) | Human Reproduction vol 13 no 11 pp 3256-3261 1998 |
| 1998 | Electron Microscopy of Cryopreserved Human Spermatozoa, (Abstract), | Avery, S., Morris, G.J., Blayney, M.L | Human Reproduction.13 (1): 279 |
| 1997 | Transrectal electroejaculation combined with in-vitro fertilization: effective treatment of anejaculatory infertility due to spinal cord injury | Brinsden, P. R., Avery, S., Marcus, S., and Macnamee, M., (1997) | Human Reproduction vol 12 no 12 pp 2687-2692 1997 |
| 1996 | Human embryo freezing: current conditions and concerns | Brinsden, P. R., (1996) | British Journal of Obs & Gynae October 1995 Vol 102 pp 767-772 |
| 1995 | The prediction of ectopic pregancy after in-vitro Fertilization and embryo transfe | Marcus, S. F., Macnamee, M., and Brinsden, P., (1995) | Human Reproduction vol 10 no 8 pp 2165 – 2168 |
| 1995 | Diagnosis, prevention and management of ovarian hyperstimulation syndrome | Brinsden, P., Balen A et al (1995) | British Journal of Obs & Gynae October 1995 Vol 102 pp 767-772 |
| 1995 | An evaluation of the effect of Pentoxyphilline on sperm function and treatment outcome of male-factor infertility: A preliminary study. | Fountain, S., Rizk, P., Avery, S., Palmer, C., Blayney, M., Mills, C., Brinsden, P., | Journal of Assisted Reproduction and Genetics 12 (10). |
| 1995 | Sucessful use of Pentoxyphilline in male-factor infertility and previous failure of fertilization: A prospective randomized study. | Rizk, B., Fountain, S., Avery, S., Blayney, M., Macnamee, M., Mills, C., Brinsden, P | Journal of Assisted Reproduction and Genetics 12 (10). |
| 1995 | Stage specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos. | Sharkey, A., Dellow, K., Blayney, M., Charnock-Jones, S., Smith, S. | Biology of Reproduction 53 (4): 974-81 |
| 1994 | Tuberculous Infertility and in vitro Fertilization | Marcus, S. F., Rizk, B., Fountain, S., and Brinsden, P., | American Journal of Obs & Gynae Vol 171 No 6 pp 1593 – 1596 |
| 1994 | Birth characteristics and perinatal outcome of babies conceived from cryopreserved embryos | Wada, I., Macnamee, M.C., Wick, K., Bradfield, J. M., and Brinsden, P. R. (1994) | Human Reproduction vol 9 no 3 pp 543-546 1994 |
| 1994 | Clinical experience with highly purified FSH. Newsletter: Gonadotrophin for the 90’s | Brinsden, P.R. (1994) | Excerpta Medica Asia Ltd vol 1 no.1 |
| 1994 | High rates of pregnancy after long-term down-regulation of women with severe endometriosis | Marcus, S. F., and Edwards, R. G., | American Journal of Obs & Gynae Vol 171 No 3 pp 812 -817 |
| 1993 | Comparative trial between an ultra-short and long protocol of luteinizing hormone-releasing hormone agonist for ovarian stimulation in in-vitro Fertilization | Marcus, S. F., Brinsden, P. R., Macnamee, M., Rainsbury, P. A., Elder, K. T., and Edwards, R. G., (1993) | Human Reproduction vol 8 no 2 pp 238- 243 1993 |
| 1992 | Pronuclear, cleavage and blastocyst histories in the attempted preimplantation diagnosis of the human hydatidiform mole | Edwards, R.G., Crow, J., Dale, S., Macnamee, M.C., Hartshorne, G.M., and Brinsden, P., (1992) | Human Reproduction vol 7 994-998 |
| 1991 | Replacement of frozen-thawed embryos in artificial and natural cycles: A prospective semi-randomized study | Sathanandan, M., Macnamee, M.C., Rainsbury, R., Wick, K., Brinsden, P., Edwards, R.G. (1991) | Human Reproduction vol 6 No 5 pp 685-687 |
| 1991 | Perinatal outcome and congenital malformations in in-vitro fertilization babies from the Bourn-Hallam group | Rizk, B., Doyle, P., Tan, S.L., Rainsbury, P., Betts, J., Brinsden, P., and Edwards, R., (1991) | Human Reproduction Vol 6 no 9 pp 1259-1264 (1991) |
| 1991 | The influence of in vitro development upon post-thaw survival and implantation of cryopreserved human blastocysts | Hartshorne, G.M., Elder, K., Crow, J., Dyson, H., & Edwards, R.G (1991) | Human Reproduction 6, 136-41 |
| 1991 | Intercellular Communication in the Early Human Embryo | Dale, B., Elder, K et al (1991) | Molecular Reproduction and Development 29:22-28 (1991) |
| 1990 | Case Report Rare ectopic pregnancies after in-vitro fertilization: one unilaterla twin and four bilateral tubal pregnancies | Rizk B., Morcos S., Avery S., Elder K., Brinsden P., Mason B., & Edwards R., (1990) | Human Reproduction vol 5 no 8 pp 1025-1028 1990 |
| 1990 | Seminal plasma anti-sperm antibodies and IVF: the effect of semen sample collection into 50% serum | Elder, K.T., Wick, K.L. & Edwards, RG(1990) | Hum. Reprod.. 5, 179-84 |
| 1990 | Effect of cell number at freezing upon survival and viability of cleaving embryos generated from stimulated IVF cycles. | Hartshorne, G.M., Wick.K., Elder, K., & Dyson, H. (1990). | Human Reprod. 5, 857-61 |
| 1990 | Predictive Value of LH Concentration for Obtaining a Pregnancy going to Term | Macnamee, M., (1990) | Extrait des Actualities Gynecologiques Vingtieme Serie |
| 1990 | In vitro fertilization and development of one of two human oocytes with fused zonae pellucidae: case report. | Hartshorne, G.M., Blayney, M.L., Dyson, H., Elder.K. | Fertility and sterility 54 (5):947-9. |
| 1989 | The role of IVF in Polycystic ovarian disease | Macnamee, M., (1989) | Research and clinical forums, 11, 89-95 |
| 1989 | The use of Albuminar 5 ™ as a medium supplement in clinical IVF | Ashwood-Smith MJ, Hollands P, & Edwards RG (1989) | HR 4(6) 702-705 |
| 1989 | Short term luteinising hormone agonist treatment, prospective trial of a novel ovarian stimulation regimen for in vitro fertilization | Macnamee M.C., Howles C.M., Edwards RG et al. (1989) | Fertil. Steril. 52 264-269 |
| 1988 | The Influence of stimulation regimes and luteal phase support oon the outcome of IVF | Macnamee M.C., Edwards R.G., Howles C.M (1988) | Human Reproduction vol 3 Supple 2 pp 43 – 52 1988 |
| 1987 | Pregnancies afrer IVF when high tonic LH is reduced by long-term treatment with GnRH agonists | Macnamee M.C., Howles C.M., Edwards R.G., (1987) | Human Reproduction 2:569 |
| 1987 | Follicular development and early luteal function of conception and non-concepted cycles after human in vitro fertilization | Howles, C.M., Macnamee, M.C., & Edwards, R.G. (1987) | Hum Reprod. 2, 17-21 |
| 1986 | Factors Affecting Survival and Implantation of Cryopreserv ed Human Embryos | Cohen, J., Simons, R.S., Fehilly C B, & Edwards R G, (1986) | Journal of in Vitro Fertilization and Embryo Transfer Vol 3 No 1 1986 |
| 1986 | Effect of high tonic levels of luteinizing hormone on outcome of in vitro fertilization | Howles, C.M., Macnamee, M.C., Edwards, R.G., Goswamy, R., , P.C. (1986) | Lancet, 2, 521-522 |
| 1986 | Observations on 767 clinical pregnancies and 500 live births after human in vitro fertilisation | Steptoe, P.C. and Edwards, R.G., Walters, D.E. (198 | Human Reproduction, 1, 89-94 |
| 1985 | Treatment of idiopathic infertility, cervical mucus hostility, and male infertility: artificial insemination with husband’s semen or in vitro fertilization? | Hewitt, J., Cohen, J., Krishnaswamy, V., Fehilly, C. B., Steptoe, P.C., Walter,D. E., (1985) | Fertility and Sterility vol 44 No 3 September 1985 |
| 1985 | Seminal Bacterial pathogens and in Vitro Fertilization – Short Communications | Hewitt, J., Cohen, J., Fehilly, C B., et al (1985) | Journal of in Vitro Fertilization and Embryo Transfer Vol 2 No 2 1985 |
| 1985 | Pregnancies following the frozen storage of expanding human blastocysts | Cohen, J., Simons, R.F., Edwards R G, Fehilly C B, Fishel S B. (1985) | J IVF ET 2, 59-64 |
| 1985 | In vitro fertilisation: a treatment for male infertility | Cohen, J., Edwards, R.G., Fehilly, C., Fishel, S., Hewitt, J., Purdy, J., Rowland, G., Steptoe, P.C., Webster, J. (1985) | Lancet 1 1239 |
| 1984 | Factors influencing the success of in vitro fertilisation for alleviating human infertility | Edwards, R.G., Fishel. S.G., Cohen, J., Fehilly, C.B., Purdy, J.M., Steptoe, P.C., Webster, J.M. (1984) | J. In Vitro Fertil & ET, 1, 3-23 |
| 1983 | Current Status of In-Vitro Fertilisation and Implantatnion of Human Embryos | Edwards, R G and Steptoe, P C (1983) | The Lancet – Saturday 3 December 1983 |
| 1978 | Birth after the reimplantation of a human embryo (letter) | Steptoe, P.C. and Edwards, R.G, (1978) | Lancet, 2, 366 |
| 1976 | Reimplantation of a human embryo with subsequent tubal pregnancy | Steptoe, P.C. and Edwards, R.G, (1976) | Lancet, 1. 880-882 |
| 1969 | Laparoscopy: Diagnostic and Therapeutic Uses | Steptoe, P.C., (1969) | Proceedings of the Royal Society of Medicine May 1969 vol 62 No 5 pp 439-441 |
Bourn Hall Clinic
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to be part of such a
professional team"
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